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Carla Linder-Mayer

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Bottle of Protandim NAD
Bottle of Protandim NAD
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Protandim® NAD Synergizer*

Protandim® NAD Synergizer was specifically formulated to target NAD, and has been shown to double sirtuin activity in 24 hours. Supporting increased health, focus, energy, mental clarity, and mood. *

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Beyond NAD

Recently, scientists have been sharing the immense importance of proteins called sirtuins. Studies are showing sirtuin activity comes with a cascade of health benefits. Including supporting a healthy vascular system, maintaining cholesterol levels already in the healthy range, supporting the body’s healthy inflammatory response, supporting joint health, heightening mental focus, improving mood, motivation, energy, and much more. However sirtuin activity declines as we age (≃60%).

Researchers have discovered that sirtuin activity can be increased through drastic caloric restriction (reducing calories by 40-60%). A typical caloric restriction diet can increase sirtuin activity 94%. Obviously this drastic approach runs the risk of nutrient deficiency and is not recommended without medical supervision.

So, with the knowledge that sirtuin activation requires the molecule NAD, we went to work. Protandim® NAD Synergizer was specifically formulated to target NAD, and has been shown to double sirtuin activity in 24 hours, supporting increased health, focus, energy, mental clarity, and mood. *


  • Supports healthy longevity *
  • Supports autophagy (removal of cellular waste) *
  • Improves mental focus and concentration *
  • Supports positive mood and motivation *
  • Boosts mental and physical energy *
  • Supports body's healthy inflammatory response *
  • Maintain cholesterol levels already in the healthy range *
  • Supports healthy vascular system *



Cell signaling pathways are essential for your survival and your health—both short- and long-term.

When you are young, these cell signaling pathways work well, respond quickly, and allow you to robustly adapt to whatever your environment throws at you. However, as we age, these cell signaling pathways begin to stop working as efficiently and ultimately the adaptive response slows.

Increase sertuin activity

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Top FAQ's

  • Yes, if you purchase the Vitality Stack (packets/bottles), Activated Essentials, or the Ultimate Stack, you will receive free shipping. If you add additional products to your order when ordering these stacks, your entire order will ship for free.

  • Vegetable-based capsules.

  • It is recommended to only use according to the directions on the label (two capsules per day).

  • No. We have not tested Protandim NAD Synergizer on pets and do not recommend giving it to our furry loved ones. We do recommend giving your pets Petandim, it’s a dog-friendly formulation.

  • Yes, Protandim NAD Synergizer is Vegetarian.


  • Wasabi, or Japanese horseradish, is a cruciferous vegetable that grows naturally in shady and humid climates around the world. Extracts from the wasabi root (rhizome) are rich in isothiocyanates. Isothiocyanates have been shown to be potent activators of many different types of genetics and metabolic processes. *

  • As the name suggests, olive leaf extract is derived from the leaves of the olive tree. Extracts from olive leaf contain many healthy compounds, most notably hydroxytyrosol. Hydroxytyrosol is a phenolic phytonutrient shown to have many health promoting activities such as supporting a healthy inflammation response, a healthy lipid profile (towards maintaining a healthy cholesterol level already within a normal range), and a healthy gut. It additionally supports gene expression, autophagy (or cellular cleanup), and antioxidant activity. *

  • Cuprous niacin is the complex between the vitamin niacin (vitamin B3) and the mineral copper but in its reduced or activated form. Copper is an essential cofactor for many physiological pathways including iron metabolism, nerve function, and energy production. Niacin is an important precursor for NAD synthesis. NAD is important to support energy production in the cell but also an essential cosubstrate for the family of enzymes known as sirtuins. *

  • Theacrine (1,3,7,9-tetramethyluric acid) is the predominant purine found in the tea Camellia kucha. It is psychostimulant structurally similar to caffeine. Theacrine’s multi-faceted effects come from the reactions between two neural pathways: dopaminergic and adenosinergic pathways. By affecting these major pathways, theacrine increases energy without irritability or habituation and helps enhance physical and mental performance. *

Label Info

Serving Size
2 Capsules
Servings Per Container
Amount Per Serving Amount DV% **
Niacin 870mcg NE 5%
Copper 187mcg 21%
Proprietary Blend 462mg
Wasabi Rhizome Powder
Olive Leaf Extract
Cuprous Niacin
Other Ingredients

Rice Flour, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide.



Adults, take two capsules daily with breakfast.

Adults, take two capsules daily with breakfast.

Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing.


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* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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